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It was believed that the Janus-faced molecule serves as an antioxidant or a prooxidant depending on its local concentrations. At lower concentrations, H 2 S exerts beneficial effects like protective effects in the cardiovascular system as we mentioned before, while at higher concentrations, H 2 S exhibits a variety of deleterious/cytotoxic The group has created double-faced gamma PNAs called Janus gamma PNAs. Named after the two-faced Roman god, Janus PNAs are able to recognize and bind with both strands of a DNA or RNA molecule. 1996-11-1 · Lipid particle-localized triacylglycerol (TAG) lipase. The lipid droplet/particle is a lipid storage compartment which serves as a depot of energy and building blocks for membrane lipid biosynthesis. Involved in the mobilization of the non-polar storage lipids triacylglycerols (TAGs) from lipid particles by hydrolysis of TAGs, releasing and supplying specific fatty acids to the appropriate A molecule is an electrically neutral group of two or more atoms held together by chemical bonds. Molecules are distinguished from ions by their lack of electrical charge.

Janus faced molecule

Janus‐Faced, Dual‐Conductive Notably, the unusual porous microstructure of the top layer is theoretically elucidated using molecular dynamics simulation. Rare “Janus”-faced single-molecule magnet exhibiting intramolecular ferromagnetic interactions A rare disk-like single-molecule magnet (SMM) exclusively bridged by end-on azides with a spin ground state of S = 14 was prepared by the reaction of a divalent Fe II precursor with Me 3 SiN 3 under basic conditions. Ly turned his focus to developing Janus PNAs. Named after the two-faced Roman god, Janus PNAs are double-sided, allowing them to bind to both strands of a DNA and RNA molecule. This hairpin structure in the Huntington’s RNA seemed that it would be a promising target for the Janus PNAs. idant/radical scavenging ability. The Roman god Janus, shown in ancient coins as having two faces in one body, inspired the designation of ‘Janus molecules’ for these substances.

molecu lar w eight prote in) th at is subse quent ly red Named after the two-faced Roman god, Janus PNAs are double-sided, allowing them to bind to both strands of a DNA and RNA molecule.

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Inflammation research 52 (2), 56-63, 2003. 250, 2003. Diphenyl diselenide a janus-faced molecule.

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As a one- https://janusinfo.se/download/18.840e7ca163033c061f1dbac/1535626617577/Nusinerse Discovery of small molecule splicing.

Although lethal to a wide range of invertebrates, their molecular target has remained enigmatic for almost a decade. We demonstrate here that these toxins are selective, Thus, neurons, in contrast to astrocytes, appear particularly vulnerable to the effects of nitrosative stress. This article reviews the current understanding of the cytotoxic versus cytoprotective effects of NO in the central nervous system, highlighting the Janus-faced properties of this small molecule. Request PDF | Double-faced Janus molecules | A pretty elastic skin: surface tension – Molecular schizophrenia: the surfactants – A multitude of multicolored bubbles – Foams: when a blind man 2021-04-15 Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells. DIT is not only a mechanism of inherited drug resistance, but proliferating DIT cells can produce progeny with increased ploidy or aneuploid genomes that drive aggressive disease.
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Find this author on Google Scholar. 2020-05-15 · Janus-faced: molecular mechanisms and versatile nature of renal fibrosis . Hiroyuki Arai. 1, Motoko Yanagita.

2017-12-05 Besides their vital role in hemostasis and thrombosis, platelets are also recognized to be involved in cancer, where they play an unexpected central role: They actively influence cancer cell behavior, but, on the other hand, platelet physiology and phenotype are impacted by tumor cells. The existence of this platelet-cancer loop is supported by a large number of experimental and human studies Janus-faced atracotoxins block K Ca channels 2 ABSTRACT The Janus-faced atracotoxins area unique family of excitatory peptide toxins that contain a rare vicinal disulfide bridge. Although lethal to a wide range of invertebrates, their molecular target has remained enigmatic for almost a decade. We demonstrate here that these toxins are selective, Thus, neurons, in contrast to astrocytes, appear particularly vulnerable to the effects of nitrosative stress. This article reviews the current understanding of the cytotoxic versus cytoprotective effects of NO in the central nervous system, highlighting the Janus-faced properties of this small molecule. Request PDF | Double-faced Janus molecules | A pretty elastic skin: surface tension – Molecular schizophrenia: the surfactants – A multitude of multicolored bubbles – Foams: when a blind man 2021-04-15 Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells.
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With complex molecular dynamic simulations on a supercomputer, they unmasked the Janus-faced nature of mechanochemistry. Up to a certain force, the reaction rate increases in proportion to the force. The Janus-faced nature of the C 2 B domain is fundamental for synaptotagmin-1 function the bottom face of one C 2 B domain molecule is insufficient for lipid binding in the absence of Ca 2+, Vector Illustration of the Historical Timeline Royal banner of Janus of Cyprus. Janus with title. Janus - god having two faces in ancient Roman mythology. Janus kinase 2, a non-receptor tyrosine kinase which has been implicated in signaling by members of the type II cytokine receptor.

idant/radical scavenging ability. The Roman god Janus, shown in ancient coins as having two faces in one body, inspired the designation of ‘Janus molecules’ for these substances.
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molecu lar w eight prote in) th at is subse quent ly red Figure 1: All-cis 1,2,3,4,5,6-hexafluorocyclohexane 1 is a facially polarized, 'Janus-headed' molecule that can be made in six steps from compound 2. Renal fibrosis is a major hallmark of CKD, regardless of the underlying etiology. In fibrosis development and progression, myofibroblasts play a pivotal role, producing extracellular matrix and interacting with various resident cells in the kidney. Over the past decade, the origin of myofibroblasts has been thoroughly investigated.